AVEO Pharmaceuticials is a cancer therapeutics company focused on discovering, developing and commercializing targeted cancer therapies. Co.'s primary drug candidate, tivozanib, is designed to provide an optimal blockade of the vascular endothelial growth factor ("VEGF") pathway by inhibiting three VEGF receptors: VEGF receptors 1, 2 and 3. In addition to tivozanib, Co. has a pipeline of monoclonal antibodies derived from its Human Response Platform, a method of building preclinical models of human cancer. Ficlatuzumab, Co.'s secondary product candidate, is an antibody which binds to hepatocyte growth factor thereby blocking its function.
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